| Bioactivity | Jacaric acid is a conjugated linolenic acid, which inhibits viability in cells PC-3 (IC50 is 11.8 μM), LNCaP (IC50 is 2.2 μM) and DLD-1, induces apoptosis and necrosis[1]. Jacaric acid exhibits anticaner activity against prostate cancer and adenocarcinoma[2]. Jacaric acid exhibits immunomodulating activity in murine peritoneal macrophages as an immunopotentiator[3]. Jacaric acid is orally active. |
| Invitro | Jacaric acid (0-10 μM) 剂量和时间依赖性地通过内在途径诱导 PC-细胞凋亡 (apoptosis)，通过内在途径和外在途径诱导 LNCaP 细胞凋亡 (apoptosis)[1]。Jacaric acid (0-10 μM) 通过细胞内掺入在 DLD-1 细胞内表达细胞毒性，并通过脂质过氧化诱导细胞凋亡 (apoptosis)[2]。Jacaric acid (50-100 μM) 通过分泌细胞因子 IFN-γ、IL-1β 和 TNF-α 来激活巨噬细胞，增强小鼠腹腔巨噬细胞的内吞活性，并对 MBL-2 细胞表达细胞抑制活性[3 ]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Jacaric acid 相关抗体: Western Blot Analysis[1] Cell Line: |
| In Vivo | Jacaric acid (1 mg/day/mouse，口服 36 天) 在移植 DLD-1 的无胸腺裸鼠中表现出抗肿瘤活性，且无明显毒性[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 28872-28-8 |
| Formula | C18H30O2 |
| Molar Mass | 278.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Gasmi J, et al., Jacaric acid and its octadecatrienoic acid geoisomers induce apoptosis selectively in cancerous human prostate cells: a mechanistic and 3-D structure-activity study. Phytomedicine. 2013 Jun 15;20(8-9):734-42.. [2]. Shinohara N, et al., Jacaric acid, a linolenic acid isomer with a conjugated triene system, has a strong antitumor effect in vitro and in vivo. Biochim Biophys Acta. 2012 Jul;1821(7):980-8. [3]. Liu WN, et al., The Immunomodulatory Activity of Jacaric Acid, a Conjugated Linolenic Acid Isomer, on Murine Peritoneal Macrophages. PLoS One. 2015 Dec 2;10(12):e0143684. |