JZP-MA-11_product_DataBase

Bioactivity	JZP-MA-11 is a positron emission tomography (PET) ligand targeting the endocannabinoid α/β-hydrolase domain 6 (ABHD6) enzyme. JZP-MA-11 selectively inhibits ABHD6 with an IC50 value of 126 nM. JZP-MA-11 can cross the blood-brain barrier (BBB). [18F]JZP-MA-11 has the potential for preclinical evaluation targeting the brain ABHD6 in mice and nonhuman primate (NHP)[1].
Invitro	JZP-MA-11 (10 μM) 对表达 CB1 或 CB2 的 HEK293 细胞中毛喉素 (HY-15371) 刺激的 cAMP 没有影响[1]。
In Vivo	JZP-MA-11 (1.5 mg/kg; 静脉给药; 示踪剂注射前 20 分钟) 导致大脑、肝脏、心脏和肾脏等富含 ABHD6 的器官的放射性摄取减少[1]。 Animal Model:
Name	JZP-MA-11
CAS	1672691-50-7
Formula	C15H17FN4O2S
Molar Mass	336.38
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Karine Mardon, et al.Utilizing PET and MALDI Imaging for Discovery of a Targeted Probe for Brain Endocannabinoid α/ β-Hydrolase Domain 6 (ABHD6). J Med Chem. 2022 Dec 14.

PeptideDB