| Bioactivity | JZP-430 is a potent, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) with an IC50 of 44 nM, exhibits ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL)[1]. | ||||||||||||
| Target | IC50: 44 nM (ABHD6, human) | ||||||||||||
| Name | JZP-430 | ||||||||||||
| CAS | 1672691-74-5 | ||||||||||||
| Formula | C16H26N4O3S | ||||||||||||
| Molar Mass | 354.47 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Patel JZ, et al. Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors. ChemMedChem. 2015 Feb;10(2):253-65. |