| Bioactivity | JX237 is an inhibitor of the epithelial neutral amino acid transporter B0AT1 (SLC6A19) with an IC50 value of 31 nM. JX237 is the main transporter for the absorption of neutral amino acids in the intestines and their reabsorption in the kidneys. By inhibiting B0AT1, JX237 can help normalize elevated plasma amino acids in rare amino acid metabolic disorders like phenylketonuria and urea cycle disorders[1]. |
| CAS | 1021125-90-5 |
| Formula | C11H15BrN2O |
| Molar Mass | 271.15 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xu J, et al. Molecular basis of inhibition of the amino acid transporter B0AT1 (SLC6A19). Nat Commun. 2024 Aug 22;15(1):7224. |