| Bioactivity | JV-1-36 acetate is a growth hormone-releasing hormone (GHRH) antagonist. JV-1-36 acetate inhibits the production of reactive oxygen species in A549 lung cancer cells. JV-1-36 can be used to study the effect of GHRH antagonists in vitro [1]. | ||||||
| Target | IC50: growth hormone-releasing hormone (GHRH). | ||||||
| Invitro | JV-1-36 (0.01-15 μM; 8 h) 在 A549 细胞中，较高浓度 (5-15 μΜ) 下降低细胞活力。(2-15 μM; 8 h) 在 Hela 细胞中降低细胞活力[1]。JV-1-36 (1 μM; 8 h) 在 A549 肺癌细胞显著降低 H2O2 (0.1 mM; 8 h) 诱导的 ROS 的产生，具有抗氧化的作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> JV-1-36 acetate 相关抗体: | ||||||
| Sequence | {N-(2-phenylacetyl)}-Tyr-{d-Arg}-Asp-Ala-Ile-{4-Cl-Phe}-Thr-Asn-{Har}-{Tyr(Me)}-Arg-Lys-Val-Leu-{Abu}-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-{Nle}-{d-Arg}-{Har}-NH2 | ||||||
| Shortening | {N-(2-phenylacetyl)}-Y-{d-Arg}-DAI-{4-Cl-Phe}-TN-{Har}-{Tyr(Me)}-RKVL-{Abu}-QLSARKLLQDI-{Nle}-{d-Arg}-{Har}-NH2 | ||||||
| Formula | C172H284ClN53O41.xC2H4O2 | ||||||
| Molar Mass | 3785.88 (free base) | ||||||
| Appearance | 固体 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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| Reference | [1]. Kubra KT, et al. Growth Hormone-Releasing Hormone Antagonist JV-1-36 Suppresses Reactive Oxygen Species Generation in A549 Lung Cancer Cells. Endocrines. 2022 Dec;3(4):813-820. |
JV-1-36 acetate
CAS: F: C172H284ClN53O41.xC2H4O2 W: 3785.88 (free base)
JV-1-36 acetate is a growth hormone-releasing hormone (GHRH) antagonist. JV-1-36 acetate inhibits the production of reac
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