| Bioactivity | JQ1-TCO (JQ1-trans-cyclooctene) is a derivative of JQ1 (HY-13030), an inhibitor of BET. JQ1-TCO is suitable for click chemistry and can be used as molecular probes in vitro and in vivo[1][2]. |
| Invitro | JQ1-TCO (10 μM; 18 h) 在 HeLa 细胞中不会诱导 BRD4 的显著降解[1]。 |
| Name | JQ1-TCO |
| CAS | 2087490-43-3 |
| Formula | C31H37ClN6O3S |
| Molar Mass | 609.18 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hu Z, et al. Recent Developments in PROTAC-Mediated Protein Degradation: From Bench to Clinic. Chembiochem. 2022 Jan 19;23(2):e202100270. [2]. Tyler DS, et al. Click chemistry enables preclinical evaluation of targeted epigenetic therapies. Science. 2017 Jun 30;356(6345):1397-1401. |
JQ1-TCO
CAS: 2087490-43-3 F: C31H37ClN6O3S W: 609.18
JQ1-TCO (JQ1-trans-cyclooctene) is a derivative of JQ1 (HY-13030), an inhibitor of BET. JQ1-TCO is suitable for click ch
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