| Bioactivity | JNK3 inhibitor-5 (Compound 22b) is a potent and selective JNK3 inhibitor with an IC50 of 0.379 nM. JNK3 inhibitor-5 effectively protects the neuronal cells against amyloid beta-induced apoptosis. JNK3 inhibitor-5 has a high cell permeability and is predicted as BBB permeable[1]. |
| Invitro | JNK3 inhibitor-5 (Compound 22b) (10 μM; 24 h) 显示对淀粉样蛋白诱导的细胞凋亡有神经保护作用[1]。 Cell Viability Assay[1] Cell Line: |
| Name | JNK3 inhibitor-5 |
| CAS | 2911640-63-4 |
| Formula | C26H27Cl2N7O2 |
| Molar Mass | 540.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jun J, et al. Novel 1,4,5,6-tetrahydrocyclopenta[d]imidazole-5-carboxamide-based JNK3 inhibitors: Design, synthesis, molecular docking, and therapeutic potential in neurodegenerative diseases. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114917. |
JNK3 inhibitor-5
CAS: 2911640-63-4 F: C26H27Cl2N7O2 W: 540.44
JNK3 inhibitor-5 (Compound 22b) is a potent and selective JNK3 inhibitor with an IC50 of 0.379 nM. JNK3 inhibitor-5 effe
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