| Bioactivity | JNK3 inhibitor-3 (compound 15g) is a selective, BBB permeable and orally active c-Jun N-terminal kinase 3 (JNK3) inhibitor. JNK3 inhibitor-3 has inhibitory activities to JNK1, JNK2 and JNK3 with IC50 values of 147.8, 44.0 and 4.1 nM, respectively. JNK3 inhibitor-3 significantly improves the memory in mouse dementia model. JNK3 inhibitor-3 can be used for the research of Alzheimer’s disease[1]. |
| Invitro | JNK3 inhibitor-3 (0-10 μM) 对 JNK1，JNK2 和 JNK3 具有抑制活性，IC50 值分别为 147.8，44.0 和 4.1 nM[1]。JNK3 inhibitor-3 (20 μM; 24-48 h) 表现出体外神经保护作用[1]。 Cell Viability Assay[1] Cell Line: |
| In Vivo | JNK3 inhibitor-3 (30 和 60 mg/kg；口服，每天 1 次，连续 2 或 2.2 个月) 改善 3xTg 小鼠痴呆模型的记忆[1]。 Animal Model: |
| Name | JNK3 inhibitor-3 |
| Formula | C26H25N7O2 |
| Molar Mass | 467.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jun J, et al. Discovery of novel imidazole chemotypes as isoform-selective JNK3 inhibitors for the treatment of Alzheimer's disease. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114894. |