| Bioactivity | JNK-1-IN-1 is a JNK-1 inhibitor. JNK-1-IN-1 also inhibits MKK7 with an IC50 of 7.8μM. JNK-1-IN-1 bind to MKK7cp and acts as an inhibitor of JNK-1[1]. |
| Invitro | JNK-1-IN-1 (Compound 2) 对 HepG2 人肝癌细胞中的 Jnk1-u、p38α-u、ERK2-u 具有亲和力，Kd 值分别为 11、18、18[1]。JNK-1-IN-1 抑制 HepG2 人肝癌细胞中的 MKK7cp，IC50 值为 7.8[1]。 |
| Name | JNK-1-IN-1 |
| CAS | 1262406-02-9 |
| Formula | C24H22N6S |
| Molar Mass | 426.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Comess KM, et al. Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases. ACS Chem Biol. 2011 Mar 18;6(3):234-44. |
JNK-1-IN-1
CAS: 1262406-02-9 F: C24H22N6S W: 426.54
JNK-1-IN-1 is a JNK-1 inhibitor. JNK-1-IN-1 also inhibits MKK7 with an IC50 of 7.8μM. JNK-1-IN-1 bind to MKK7cp and act
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