JNJ-DGAT2-A_product_DataBase

Bioactivity	JNJ-DGAT2-A is a selective diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 value of 0.14 μM in human DGAT2-expressing Sf9 insect cell membranes. JNJ-DGAT2-A can be used for the research of triglyceride (TG) synthesis[1].
Target	IC50: 0.14 μM (Sf9 insect cell membranes DGAT2)
Invitro	JNJ-DGAT2-A (5 μM) inhibits about 99% of recombinant DGAT2 enzymatic activity[1].JNJ-DGAT2-A (5 μM) inhibits the DGAT activity in HepG2 cell lysates[1].JNJ-DGAT2-A (0.3125, 0.625, 1.25, 2.5, 5, 10, and 20 µM; 60 min prior to isotope-labeled and additional 2 h after isotope-labeled) dose-dependently inhibits the generation of TG (52:2), TG (54:3), and TG (50:2) using 13C3-D5-glycerol as a substrate in HepG2 cells with IC50 values of 0.85 μM, 0.99 μM, and 0.66 μM, respectively[1].
Name	JNJ-DGAT2-A
CAS	1962931-71-0
Formula	C24H16BrFN4O2S
Molar Mass	523.38
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Reference	[1]. Qi J, et al. The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2. J Lipid Res. 2012 Jun;53(6):1106-16.

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