| Bioactivity | JNJ-6204 is a dual inhibitor for CSNK1D (Casein Kinase 1 Delta) and CSNK1E (Casein Kinase 1 Epsilon) (CSNK1D IC50=2.3 nM; CSNK1E IC50=137 nM). JNJ-6204 shows good brain exposure[1][2]. |
| Target | IC50: 2.3 nM (CSNK1D) |
| Invitro | JNJ-6204 inhibits CSNK1D in the BRET whole cell binding assay and in the PER2 translocation whole cell functional assay with IC50s of 72 nM and 542 nM, respectively[2]. |
| Name | JNJ-6204 |
| CAS | 2765264-50-2 |
| Formula | C19H11D6FN6O |
| Molar Mass | 370.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Terry Patrick LEBOLD, et al. Casein kinase 1 delta modulators. WO2022058920A1. [2]. https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/JNJ-6204 |
JNJ-6204
CAS: 2765264-50-2 F: C19H11D6FN6O W: 370.41
JNJ-6204 is a dual inhibitor for CSNK1D (Casein Kinase 1 Delta) and CSNK1E (Casein Kinase 1 Epsilon) (CSNK1D IC50=2.3 nM
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