JNJ-40255293_product_DataBase

Bioactivity	JNJ-40255293 is a high-affinity human A 2A receptor antagonist with a KiKi of 7.5 nM. JNJ-40255293 can be used in the research of neurodegenerative diseases such as Parkinson's disease[1].
In Vivo	JNJ-40255293 (0.1-10 mg/kg, p.o.) 可以逆转氟哌啶醇 (HY-14538) 诱导的雄性 Balb/c 小鼠僵直症。在雄性 Wistar 大鼠中，JNJ-40255293 也可以剂量依赖性地逆转氟哌啶醇（0.63 mg/kg，皮下注射）诱导的强直性昏厥，增强主动觉醒，显着逆转利血平(HY-N0480)引起的运动活性缺陷[1]。
Name	JNJ-40255293
CAS	1147271-25-7
Formula	C23H22N4O3
Molar Mass	402.45
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. John R Atack, et al. JNJ-40255293, a novel adenosine A2A/A1 antagonist with efficacy in preclinical models of Parkinson's disease. ACS Chem Neurosci. 2014 Oct 15;5(10):1005-19.

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