| Bioactivity | JNJ-3790339, a Ritanserin (HY-10791) analog, is a potent and selective diacylglycerol kinase (DGKα) inhibitor with an IC50 of 9.6 μM. JNJ-3790339 has induction of toxicity in malignant cells, and improves ability to upregulate T cell activation[1]. |
| Target | IC50: 9.6 μM (DGKα) |
| Invitro | JNJ-3790339 (5-40 μM; 48 h) exhibits cytotoxic efficacy against A375, U251 and Jurkat T[1].JNJ-3790339 (5 μM; 6 h) promotes activation of primary murine T cells[1]. Cell Cytotoxicity Assay[1] Cell Line: |
| Name | JNJ-3790339 |
| CAS | 93076-87-0 |
| Formula | C30H33N3OS |
| Molar Mass | 483.67 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Granade ME, et al. Identification of ritanserin analogs that display DGK isoform specificity. Biochem Pharmacol. 2022 Mar;197:114908. |
JNJ-3790339
CAS: 93076-87-0 F: C30H33N3OS W: 483.67
JNJ-3790339, a Ritanserin (HY-10791) analog, is a potent and selective diacylglycerol kinase (DGKα) inhibitor with an I
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