| Bioactivity | JNJ-1289 is a potent, selective, competitive and allosteric human spermine oxidase (hSMOX) inhibitor (IC50: 50 nM). JNJ-1289 can be used in the research of polyamine catabolism, inflammation and cancers[1]. |
| Target | IC50: 50 nM (hSMOX);>2 μM (hPAOX and LSD1). |
| Invitro | JNJ-1289 (0 and 2 h) inhibits hSMOX activity in a time-dependent manner[1].JNJ-1289 initially forms a weak complex with hSMOX with an apparent Ki value of 1.4 μM, followed by a relatively slow protein isomerization that forms the final tightly bound inhibitor-enzyme complex[1]. |
| Name | JNJ-1289 |
| CAS | 792898-18-1 |
| Formula | C16H12N4OS |
| Molar Mass | 308.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Elsie Diaz, et al. B Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor. Commun Biol. 2022 Aug 5;5(1):787. |