| Bioactivity | JNJ 10329670 is a potent and selective noncovalent cathepsin S inhibitor with a Ki value of 34 nM for human cathepsin S. JNJ 10329670 blocks invariant chain proteolysis in B cells and dendritic cells, as well as antigen-induced T cell proliferation[1]. |
| Invitro | JNJ 10329670 (0-100 μM) 抑制组织蛋白酶 S，从而阻断人 B 细胞系中不变链的蛋白水解[1]。JNJ 10329670 (0-10 μM) 可阻断响应两种抗原的 T 细胞增殖，但对非特异性 T 细胞丝裂原植物血凝素的作用较小[1]。 |
| Name | JNJ 10329670 |
| CAS | 400797-24-2 |
| Formula | C30H34ClF3N6O3S |
| Molar Mass | 651.14 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Thurmond RL, et, al. Identification of a potent and selective noncovalent cathepsin S inhibitor. J Pharmacol Exp Ther. 2004 Jan;308(1):268-76. |
JNJ 10329670
CAS: 400797-24-2 F: C30H34ClF3N6O3S W: 651.14
JNJ 10329670 is a potent and selective noncovalent cathepsin S inhibitor with a Ki value of 34 nM for human cathepsin S.
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