| Bioactivity | JNJ-10311795 (RWJ-355871), a potent dual inhibitor of neutrophil cathepsin G (Ki = 38 nM) and mast cell chymase (Ki = 2.3 nM), exhibits noteworthy antiinflammatory activity[1]. |
| Target | Ki: 38 nM (cathepsin G), 2.3 nM (chymase). |
| Name | JNJ-10311795 |
| CAS | 518062-14-1 |
| Formula | C40H35N2O6P |
| Molar Mass | 670.69 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lawrence de Garavilla, et al. A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo. J Biol Chem. 2005 May 6;280(18):18001-7. |
JNJ-10311795
CAS: 518062-14-1 F: C40H35N2O6P W: 670.69
JNJ-10311795 (RWJ-355871), a potent dual inhibitor of neutrophil cathepsin G (Ki = 38 nM) and mast cell chymase (Ki = 2.
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