JNJ 10181457 dihydrochloride_product_DataBase

Bioactivity	JNJ-10181457 is a neutral, potent, brain-penetrant and selective non-imidazole H3 antagonist which increases NE and ACh concentrations in rat frontal cortex. JNJ-10181457 can be used for neurological research[1].
In Vivo	JNJ-10181457 (10 mg/kg, 腹腔注射, 60 min) 逆转 Imetit (HY-101173, 3 mg/kg, 皮下注射)-诱导的大鼠舔水行为与 Scopolamine (HY-N0296, 0.06 mg/kg, 腹腔注射)-诱导的 DNMTP 任务中错误反应的增加[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	544707-20-2
Formula	C20H30Cl2N2O
Molar Mass	385.37
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Galici R, et al. JNJ-10181457, a selective non-imidazole histamine H(3) receptor antagonist, normalizes acetylcholine neurotransmission and has efficacy in translational rat models of cognition. Neuropharmacology. 2009 Jun;56(8):1131-7.

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