| Bioactivity | JLB2-110c activates MCRs receptor (mMC4R EC50 = 0.34 nM) and has a strong in vivo appetite suppressant effect[1]. |
| CAS | 3032608-72-0 |
| Sequence | Cyclo(Pro-His-{d-Phe}-Arg-Trp-{Dap}-{Lys(Ac-Arg-Arg-Arg)}-{d-Pro}) |
| Shortening | Cyclo(PH-{d-Phe}-RW-{Dap}-{Lys(Ac-RRR)}-{d-Pro}) |
| Formula | C71H108N28O12 |
| Molar Mass | 1545.80 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ericson MD, et al. Incorporation of Three Extracyclic Arginine Residues into a Melanocortin Macrocyclic Agonist (c[Pro-His-DPhe-Arg-Trp-Dap-Lys(Arg-Arg-Arg-Ac)-DPro]) Decreases Food Intake When Administered Intrathecally or Subcutaneously Compared to a Macrocyclic Ligand Lacking Extracyclic Arginine Residues (c[Pro-His-DPhe-Arg-Trp-Dap-Ala-DPro)]. ACS Pharmacol Transl Sci. 2024 Apr 2;7(4):1114-1125. |