| Bioactivity | JKC 301 is a selective Endothelin A receptor antagonist. JKC 301 attenuates the pressor effects of nicotine in rats. JKC 301 can be used to study cardiovascular disease caused by smoking[1][2]. |
| Target | Endothelin A receptor. |
| Name | JKC 301 |
| CAS | 136553-96-3 |
| Sequence | Cyclo({d-Asp}-Pro-{d-Ile}-Leu-{d-Trp}) |
| Shortening | Cyclo({d-Asp}-P-{d-Ile}-L-{d-Trp}) |
| Formula | C32H44N6O7 |
| Molar Mass | 624.73 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tanus-Santos JE, Sampaio RC, Hyslop S, Franchini KG, Moreno H Jr. Endothelin ET(A) receptor antagonism attenuates the pressor effects of nicotine in rats. Eur J Pharmacol. 2000 May 12;396(1):33-7. [2]. Ngoka LC, et al. Location of alkali metal binding sites in endothelin A selective receptor antagonists, cyclo(D-Trp-D-Asp-Pro-D-Val-Leu) and cyclo(D-Trp-D-Asp-Pro-D-Ile-Leu), from multistep collisionally activated decompositions. J Mass Spectrom. 2000 Feb;35(2):265-76. |