JJC8-088_product_DataBase

Bioactivity	JJC8-088 is a potent inhibitor of DAT. JJC8-088 is a novel Modafinil-derived ligands. JJC8-088 can be used to study psychostimulant use disorders[1].
In Vivo	JJC8-088 (3-30 mg/kg, i.p., 30/120 min) 可有效减少大鼠的强迫性冰毒自我给药，并增加其运动量[1]。JJC8-088 (0-30 mg/kg, i.p., 30 min prior to testing) 可引起可卡因 Cocaine 自我给药史大鼠的细胞外多巴胺 (DA) (HY-B0451) 水平的大量快速增加[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	1627576-82-2
Formula	C28H32F2N2O2S
Molar Mass	498.63
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Tunstall BJ, et al. Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats. Neuropharmacology. 2018 Mar 15;131:96-103. [2]. Newman AH, et al. Translating the atypical dopamine uptake inhibitor hypothesis toward therapeutics for treatment of psychostimulant use disorders. Neuropsychopharmacology. 2019 Jul;44(8):1435-1444.

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