| Bioactivity | JH-VIII-49 is a potent and selective CDK8 inhibitor with excellent biological activity. The synthesis of JH-VIII-49 is simplified to eight steps with an overall yield of 33%, making it suitable for large-scale production. JH-VIII-49 promotes CDK8 inhibition through its steroid skeleton design. JH-VIII-49 provides a basis for the subsequent development of more complex bivalent small molecule degraders[1]. |
| CAS | 2209084-73-9 |
| Formula | C30H40N2 |
| Molar Mass | 428.65 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8 |
JH-VIII-49
CAS: 2209084-73-9 F: C30H40N2 W: 428.65
JH-VIII-49 is a potent and selective CDK8 inhibitor with excellent biological activity. The synthesis of JH-VIII-49 is s
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