JH-131e-153_product_DataBase

Bioactivity	JH-131e-153, a diacylglycerol (DAG)-lactone, is a small molecule activator of Munc13-1, targeting the C1 domain. The activation sequence of JH-131e-153 on Munc13-1 is WT>I590≈R592A≈W588A. The C1 domain of Munc13-1 and protein kinase C (PKC) are homologous in sequence and structure. The activation sequence of JH-131e-153 on Munc13-1 and PKC was PKCα>Munc13-1>PKCε. JH-131e-153 regulates neuronal processes through Munc13-1 and can be further used in the study of neurodegenerative diseases[1].
Target	Munc13-1 C1 domain
Invitro	Munc13-1 是二酰甘油第二信使途径的靶标，在胞吐作用期间的囊泡成熟中发挥作用。通过在囊泡融合之前作用于突触囊泡启动来参与神经递质释放，并参与易释放囊泡池 (RRP) 的活性依赖性再填充。 0 --> JH-131e-153 相关抗体:
Name	JH-131e-153
CAS	742104-91-2
Formula	C22H38O5
Molar Mass	382.53
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Das J, et al. Activation of Munc13-1 by Diacylglycerol (DAG)-Lactones. Biochemistry. 2023 Aug 31.

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