| Bioactivity | JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. JG-98 shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages[1][2][3]. |
| Invitro | JG-98 (30 nM-30 μM; 72 hours) has antiproliferative activity across a range of cell lines with the EC50s between ~0.3 and 4 μM[2].JG-98 (10 μM; 48 hours) activates apoptotic mediators (cleavage of caspase-3 and PARP) in MDA-MB-231 cells[1].JG-98 destabilizes FoxM1 and relieves suppression of downstream effectors, including p21 and p27[2]. Cell Proliferation Assay[2] Cell Line: |
| Name | JG-98 |
| CAS | 1456551-16-8 |
| Formula | C24H21Cl2N3OS3 |
| Molar Mass | 534.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
JG-98
CAS: 1456551-16-8 F: C24H21Cl2N3OS3 W: 534.54
JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disru
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