| Bioactivity | JD-02 is a novel Hsp90 inhibitor. JD-02 can induce autophagy and apoptosis. JD-02 increses the level of reactive oxygen species[1]. |
| Invitro | JD-02 (0–2 μM, 24, 48, and 72 h) 抑制 HTC116 和 SW620 细胞的生长[1]。JD-02 (1 μM, 36 72 h) 诱导 HTC116 和 SW620 细胞 G0/G1 期阻滞[1]。JD-02 (1 μM, 48 h) 诱导 HTC116 和 SW620 细胞凋亡[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> JD-02 相关抗体: Cell Viability Assay[1] Cell Line: |
| In Vivo | JD-02 (5, 10, and 20 mg/kg; 腹腔注射; 21 天) 在 HCT116 细胞异种移植小鼠模型中抑制肿瘤的发展。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C23H32N6O2 |
| Molar Mass | 424.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lan N, et al. JD-02, a novel Hsp90 inhibitor, induces ROS/SRC axis-dependent cytoprotective autophagy in colorectal cancer cells. Mol Carcinog. Published online February 27, 2024. |