| Bioactivity | JC2-11 is an inhibitor of inflammatory corpuscles. JC2-11 inhibits domain-containing protein NLRC 4, absent in melanoma 2 (AIM 2) and non-canonical (NC) inflammatory corpuscles. JC2-11 reduces the secretion of caspase-1 (p20), the cleavage of gasdermin D (GSDMD), and the releases of IL-1β and lactate dehydrogenases (LDH) in inflammatory bodies. JC2-11 inhibits the activation of inflammatory bodies by destroying the production of reactive oxygen species and the activity of caspase-1[1]. |
| In Vivo | JC2-11 (250 μg/鼠；腹腔注射；单剂量) 显著抑制了 C57BL/6 小鼠模型中非典型 (NC) 炎症小体中 caspase-1 (p20) 和 IL-1β 的释放，弱化了 NC 炎症小体的激活[1]。 Animal Model: |
| Name | JC2-11 |
| CAS | 937820-89-8 |
| Formula | C17H15FO4 |
| Molar Mass | 302.30 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lee G, et al, JC2-11, a benzylideneacetophenone derivative, attenuates inflammasome activation. Sci Rep. 2022 Dec 28;12(1):22484. |
JC2-11
CAS: 937820-89-8 F: C17H15FO4 W: 302.30
JC2-11 is an inhibitor ofinflammatory corpuscles. JC2-11 inhibits domain-containing protein NLRC 4, absent in melanoma 2
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