| Bioactivity | JB061 is a nonmuscle myosin inhibitor with IC50s of 4.4 μM (Cardiac muscle myosin), 9.1 μM (Skeletal muscle myosin), and >100 μM (Smooth muscle myosin II), respectively. JB061 poorly decreases ATPase activity (IC50>200 μM). JB061 shows cytotoxicity against COS-7 cells with an IC50 value of 39 μM[1]. | ||||||||||||
| Invitro | JB061 (化合物 6a) (40 μM; 24 h) 抑制 Cos-7 细胞的胞质分裂[1]。 | ||||||||||||
| Name | JB061 | ||||||||||||
| Formula | C19H17NO4 | ||||||||||||
| Molar Mass | 323.34 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Smith JD, et al. Isoform selectivities of novel 4-hydroxycoumarin imines as inhibitors of myosin II. Eur J Med Chem. 2022 Dec 12;247:115008. |