JAMI1001A_product_DataBase

Bioactivity	JAMI1001A is a positive allosteric modulator of AMPA receptor. JAMI1001A efficaciously modulates AMPA receptor deactivation and desensitization of both flip and flop receptor isoforms[1].
Invitro	JAMI1001A binds in the solvent accessible allosteric pocket that lies at the interface between AMPA receptor ligand-binding core dimers. JAMI1001A efficaciously blocks channel desensitization and slows deactivation of the flip and flop isoforms of AMPA receptor GluA2[1].A simple kinetic model suggests that JAMI1001A independently modulates both the protein rearrangements necessary for channel desensitization and its recovery from the desensitized state, and the protein rearrangements necessary for channel deactivation (closed-cleft stability or channel gating)[1].
Name	JAMI1001A
CAS	1001019-46-0
Formula	C16H17F3N4O3S
Molar Mass	402.39
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Harms JE, et al. Functional analysis of a novel positive allosteric modulator of AMPA receptors derived from a structure-based drug design strategy. Neuropharmacology. 2013;64(1):45-52.

PeptideDB