| Bioactivity | JAK3-IN-12 (compound 5k) is a highly potent JAK3 inhibitor with IC50 values of 9.5 nM, 18 nM and 42 nM for JAK3, JAK1 and JAK2, respectively. JAK3-IN-12 can be used for researching rheumatoid arthritis[1]. |
| In Vivo | JAK3-IN-12 (compound 5k) shows moderate AUC, due to its high clearance, which resulted into overall low bioavailability[1].Pharmacokinetic Parameters of JAK3-IN-12 in male C57BL/6J mice[1]. |
| Name | JAK3-IN-12 |
| CAS | 1430095-86-5 |
| Formula | C19H19N5O4S |
| Molar Mass | 413.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bahekar R, et al. Discovery of diaminopyrimidine-carboxamide derivatives as JAK3 inhibitors. Bioorg Chem. 2020 Jun;99:103851. |
JAK3-IN-12
CAS: 1430095-86-5 F: C19H19N5O4S W: 413.45
JAK3-IN-12 (compound 5k) is a highly potent JAK3 inhibitor with IC50 values of 9.5 nM, 18 nM and 42 nM for JAK3, JAK1 an
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