| Bioactivity | JAK-IN-33 (compound 3 (R)) is a JAK inhibitor[1]. |
| Invitro | JAK-IN-33能在血液有效应用[1]。JAK-IN-33 (59 μM, 40 h) 在人体皮肤中能够显著降低由 IL4/IL3 刺激引起的 GSVA (gene set variation analysis) 评分升高，使 GSVA 评分趋于正常[1]。JAK-IN-33 (59 μM, 40 h) 在皮肤中具有可接受的稳定性，能在人体皮肤中有效应用[1]。JAK-IN-33 (0.324 μL, 40 h) 在 Franz 细胞中显著抑制了 TARC 和两个 AD (atopic dermatitis) 相关标志物 MMP12 和 Eotaxin 3 的表达[1]。JAK-IN-33 在肝脏中快速失活，与口服 JAK 抑制剂重新用于局部使用相比，JAK-IN-33 预计局部应用后会有更好的靶向全身安全性。 0 --> JAK-IN-33 相关抗体: Real Time qPCR[1] Cell Line: |
| Name | JAK-IN-33 |
| Formula | C24H27N5O5 |
| Molar Mass | 465.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Thoma G, Decoret O, et al. Design of a Supersoft Topical JAK Inhibitor, Which Is Effective in Human Skin but Rapidly Deactivated in Blood. J Med Chem. 2023;66(21):15042-15053. |