JAK-IN-24

CAS: 2042629-43-4 F: C20H25N5O2 W: 367.44

JAK-IN-24 is a JAK inhibitor, with IC50s of 0.534 and 24 nM at the presence of 4 μM or 1mM ATP, respectively. JAK-IN-24

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Bioactivity	JAK-IN-24 is a JAK inhibitor, with IC50s of 0.534 and 24 nM at the presence of 4 μM or 1mM ATP, respectively. JAK-IN-24 also inhibits PBMC IL-15 induced STAT5 phosphorylation with an IC50 of 86.171 nM[1].
Invitro	JAK-IN-24 (Example 129) 在 4 μM 或 1mM ATP 存在时抑制 JAK 的 IC50 值分别为 0.534 和 24 nM[1]。JAK-IN-24 在人全血中表现出稳定性，t1/2 为 267.223 分钟[1]。JAK-IN-24 抑制 PBMC IL-15 诱导的 STAT5 磷酸化，IC50 为 86.171 nM[1]。
Name	JAK-IN-24
CAS	2042629-43-4
Formula	C20H25N5O2
Molar Mass	367.44
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Atli Thorarensen, et al. Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl, pyrrolo[2,3-b]pyridinyl acrylamides and epoxides thereof. Patent. WO2016178110.