| Bioactivity | J-1149 is a potent ALK5 inhibitor, with an IC50 value of 0.017 μM. J-1149 also shows weak p38α MAP kinase inhibitory activity, with an IC50 value of 0.435 μM. J-1149 can be used for liver fibrosis research[1]. |
| Invitro | J-1149 (compound 15g) (5-40 μM, 24 h) 可有效抑制 TGF-β 诱导的肝星状细胞 (HSC) 中的细胞外基质 (ECM) 沉积，并最终抑制 HSC 激活[1]。 J-1149 (20 μM, 24 h) 抑制 TGF-β 刺激的 α-SMA 和胶原蛋白 I 的表达[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> J-1149 相关抗体: Western Blot Analysis[1] Cell Line: |
| In Vivo | J-1149 (compound 15g) (15 mg/kg, 口服给药, once) 表现出良好的药代动力学 (PK) 特征和良好的半衰期 (t1/2 = 9.14 h) [1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 2883580-95-6 |
| Formula | C25H24N8O |
| Molar Mass | 452.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Meng YQ, et al. Synthesis and anti-liver fibrosis activity of imidazole and thiazole compounds containing amino acids. Eur J Med Chem. 2024 Mar 13;269:116311. |