J 104871_product_DataBase

Bioactivity	J 104871 (J-104135) is a farnesyl pyrophosphate (FPP)-competitive farnesyltransferase (FTase) inhibitor. J 104871 inhibits rat brain FTase with an IC50 of 3.9 nM in the presence of farnesyl pyrophosphate (FPP)[1].
Invitro	在 0.6 μM 法呢基焦磷酸 (FPP) 存在下，J 104871 抑制大鼠脑 FTase，IC50 为 3.9 nM，而它几乎不抑制大鼠脑蛋白香叶基香叶基转移酶-I 或角鲨烯合酶 (SS)[1]。 J 104871 还抑制活化的 H-ras 转化的 NIH3T3 细胞中的 Ras 加工，IC50 值为 3.1 μM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> J 104871 相关抗体:
In Vivo	J 104871（40-80 mg/kg；腹腔注射；每日一次；6 天）抑制裸鼠异种移植模型中的肿瘤生长[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	191088-19-4
Formula	C38H32N2O12
Molar Mass	708.67
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. M Yonemoto, et al. J-104,871, a novel farnesyltransferase inhibitor, blocks Ras farnesylation in vivo in a farnesyl pyrophosphate-competitive manner. Mol Pharmacol. 1998 Jul;54(1):1-7.

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