| Bioactivity | Izumerogant (IMU-935) is an inverse agonist of retinoid-related orphan receptor-gamma (RORγ). Izumerogant (compound 123) also potently inhibits IL-17A, IL-17F and IFN-γ activity with IC50s <50 nM[1][2]. |
| Name | Izumerogant |
| CAS | 2299252-72-3 |
| Formula | C22H18ClF4N5O2 |
| Molar Mass | 495.86 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. F Jakob, et al. Isoxazole-pyrazole derivatives and related compounds as IL-17 and IFN-γ inhibitors for treating autoimmune diseases and chronic inflammation: World Intellectual Property Organization, WO2019048541. 2019-03-14. [2]. WHO Drug Information-World Health Organization (WHO). |
Izumerogant
CAS: 2299252-72-3 F: C22H18ClF4N5O2 W: 495.86
Izumerogant (IMU-935) is an inverse agonist of retinoid-related orphan receptor-gamma (RORγ). Izumerogant (compound 123
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