| Bioactivity | Izilendustat (hydrochloride) is a potent inhibitor of prolyl hydroxylase which stabilizes hypoxia inducible factor- 1 alpha (HIF- lα), as well as hypoxia inducible factor-2 (HIF-2). Izilendustat (hydrochloride) has the potential for the research of HIF- lα related diseases including Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, anemia, colitis, and other inflammatory bowel diseases (extracted from patent WO2011057115A1/WO2011057112A1/WO2011057121A1)[1][2][3]. |
| Target | prolyl hydroxylase |
| Name | Izilendustat hydrochloride |
| CAS | 1303513-80-5 |
| Formula | C22H29Cl2N3O4 |
| Molar Mass | 470.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Joseph H, et al. Prolyl hydroxylase inhibitors. Patent WO2011057115A1. [2]. Robert Shalwitz, et al. Methods for increasing the stabilization of hypoxia inducible factor-1 alpha. Patent WO2011057112A1. [3]. Joseph H, et al. Compositions and methods for treating colitis. Patent WO2011057121A1. |
Izilendustat hydrochloride
CAS: 1303513-80-5 F: C22H29Cl2N3O4 W: 470.39
Izilendustat (hydrochloride) is a potent inhibitor of prolyl hydroxylase which stabilizes hypoxia inducible factor- 1 al
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