| Bioactivity | Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor[1][2][3][4]. |
| Invitro | Itraconazole has anti-proliferation of HUVEC (IC50 of 0.16 μM)[2].Itraconazole inhibits endothelial cell cycle progression at the G1 phase in vitro[1]. |
| Name | Itraconazole |
| CAS | 84625-61-6 |
| Formula | C35H38Cl2N8O4 |
| Molar Mass | 705.63 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
Itraconazole
CAS: 84625-61-6 F: C35H38Cl2N8O4 W: 705.63
Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway anta
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