Isothiafludine_product_DataBase

Bioactivity	Isothiafludine is an orally active non-nucleosidic anti-HBV compound. Isothiafludine inhibits hepatitis B virus replication by blocking pregenomic RNA encapsidation[1].
Invitro	Isothiafludine 抑制 HBV DNA 复制，IC50 为 1.33 μM[1]。Isothiafludine (8 天) 对 HepG2.2.15 细胞的 IC50 (50% 细胞毒性) 为 50.4 μM[1]。Isothiafludine (1.25-20 μM, 48 h) 也抑制病毒转染的 Huh7 细胞中 3TC/ETV 双重耐药和 ADV 耐药 HBV 突变体的复制[1]。Isothiafludine (10-20 μM，8 天) 降低 HepG2.2.15 细胞中衣壳化的 HBV pgRNA 水平[1]。
In Vivo	Isothiafludine (口服，25-100 mg/kg，持续 15 天) 抑制 DHBV 感染鸭模型中的 DHBV DNA 复制[1]。 Animal Model:
Name	Isothiafludine
CAS	960527-22-4
Formula	C18H18FN3OS2
Molar Mass	375.48
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Yang L, et al. Isothiafludine, a novel non-nucleoside compound, inhibits hepatitis B virus replication through blocking pregenomic RNA encapsidation. Acta Pharmacol Sin. 2014 Mar;35(3):410-8.

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