| Bioactivity | Isonipecotic acid is a GABAA receptor partial agonist[1]. | ||||||||||||
| Target | GABAA Receptor | ||||||||||||
| Invitro | Isonipecotic acid inhibits [3H]GABA binding (2°C) with an IC50 of 0.33 μM[2]. | ||||||||||||
| Name | Isonipecotic acid | ||||||||||||
| CAS | 498-94-2 | ||||||||||||
| Formula | C6H11NO2 | ||||||||||||
| Molar Mass | 129.16 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Krehan D, et al. Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABA(C) receptor antagonists. Neurochem Int. 2003 Jun;42(7):561-5. [2]. Falch E, et al. GABA-mimetic activity and effects on diazepam binding of aminosulphonic acids structurally related to piperidine-4-sulphonic acid. J Neurochem. 1985 Jan;44(1):68-75. |