Isograndifoliol_product_DataBase

Bioactivity	Isograndifoliol is a selective inhibitor of butyrylcholinesterase (BChE) with an IC50 value of 0.9 μM. And Isograndifoliol moderately inhibits acetylcholinesterase (AChE) with an IC50 value of 342.9 μM. Isograndifoliol also has vasorelaxant effect and anti-tumor effect. Isograndifoliol can be used for research against dementia caused by neurodegenerative diseases[1][2][3].
Invitro	Isograndifoliol 对氯化钾或去甲肾上腺素预缩大鼠主动脉环具有剂量依赖性的血管松弛作用，EC50值为 36.36-74.51 μg/mL[2]。Isograndifoliol 对 HL-60 细胞有较强的抑制活性，IC50 值为 0.33 μM[3]。
Name	Isograndifoliol
CAS	1445475-53-5
Formula	C19H26O3
Molar Mass	302.41
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Ślusarczyk S, et al. Norditerpenoids with Selective Anti-Cholinesterase Activity from the Roots of Perovskia atriplicifolia Benth. Int J Mol Sci. 2020 Jun 23;21(12):4475. [2]. Kang J, et al. Isolation and bioactivity of diterpenoids from the roots of Salvia grandifolia. Phytochemistry. 2015 Aug;116:337-348. [3]. Tsukada H, et al. Two New Diterpenoids from Salvia przewarskii. Nat Prod Commun. 2016 Feb;11(2):159-61.

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