| Bioactivity | Isoforretin A is a bioactive and potent inhibitor against Thioredoxin-1 (Trx1) which triggers ROS-mediated antitumor effects. Isoforretin A suppresses Trx1 activity through covalently binding to the Cys32/Cys35 residues of the activation sites of Trx1 and triggers ROS accumulation, resulting in DNA damage and Apoptosis in cancer cells. Isoforretin A also inhibits the growth of HepG2 tumors in a murine xenograft model of hepatocellular carcinoma[1]. |
| CAS | 2231757-68-7 |
| Formula | C28H38O10 |
| Molar Mass | 534.60 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sun X, et al. The Natural Diterpenoid Isoforretin A Inhibits Thioredoxin-1 and Triggers Potent ROS-Mediated Antitumor Effects. Cancer Res. 2017 Feb 15;77(4):926-936. |
Isoforretin A
CAS: 2231757-68-7 F: C28H38O10 W: 534.60
Isoforretin A is a bioactive and potent inhibitor against Thioredoxin-1 (Trx1) which triggers ROS-mediated antitumor eff
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.