| Bioactivity | Iso-PPADS tetrasodium is a P2X-purinoceptor antagonist. Iso-PPADS tetrasodium inhibits P2X1 and P2X3 receptor with IC50s of 43 nM and 84 nM. Iso-PPADS tetrasodium is protective against ventilator-induced brain injury (VIBI)[1][2]. |
| Target | 43 nM and 84 nM (P2X1 and P2X3 receptor) |
| Name | Iso-PPADS tetrasodium |
| CAS | 207572-67-6 |
| Formula | C14H10N3Na4O12PS2 |
| Molar Mass | 599.30 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. González-López A, et al. Lung Purinoceptor Activation Triggers Ventilator-Induced Brain Injury. Crit Care Med. 2019 Nov;47(11):e911-e918. [2]. Brown SG, et al. Actions of a Series of PPADS Analogs at P2X1 and P2X3 Receptors. Drug Dev Res. 2001 Aug;53(4):281-291. |
Iso-PPADS tetrasodium
CAS: 207572-67-6 F: C14H10N3Na4O12PS2 W: 599.30
Iso-PPADS tetrasodium is a P2X-purinoceptor antagonist. Iso-PPADS tetrasodium inhibits P2X1 and P2X3 receptor with IC50s
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