| Bioactivity | Ischemin sodium is a CBP bromodomain inhibitor that inhibits p53 interaction with CBP and transcriptional activity in cells. Ischemin sodium salt inhibits p53-induced p21 activation with an IC50 value of 5 µM. Ischemin sodium salt also prevents apoptosis in ischemic cardiomyocytes. Ischemin sodium salt can be used in the study of cardiovascular diseases (such as myocardial ischemia)[1]. |
| Invitro | Ischemin sodium (50, 100 µM; 24 h) 抑制 U2OS 细胞中 DNA 损伤应激引起的 p53 激活[1]。Ischemin sodium (10 μM; 3 days) 通过抑制 caspase 3/7 的活性来阻断心肌细胞的凋亡[1]。Ischemin sodium salt 在 U2OS 细胞中抑制 p53 信号通路[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Ischemin sodium 相关抗体: Western Blot Analysis[1] Cell Line: |
| Formula | C15H16N3NaO4S |
| Molar Mass | 357.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Borah JC, et al. A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes. Chem Biol. 2011 Apr 22;18(4):531-41. |