| Bioactivity | Irisquinone, a natural product, is an anticancer agent. Irisquinone is also a radiation sensitizer for cancer. Irisquinone reduces GSH level and inhibits the repair of DNA singular strand breaks[1][2][3]. |
| Invitro | Irisquinone (0-128 nM, 12-48 h) 诱导大鼠 C6 胶质瘤细胞死亡[2]。Irisquinone (4.2 nM, 48 h) 增加大鼠 C6 神经胶质瘤细胞的放射敏感性[2]。 Cell Viability Assay[2] Cell Line: |
| In Vivo | Irisquinone (12.5 mg/kg，每日灌注) 使兔 VX2肺移植肿瘤模型中 Irisquinone + 放疗组瘤壁变薄，坏死面积变大[1]。 Animal Model: |
| Name | Irisquinone |
| CAS | 56495-82-0 |
| Formula | C24H38O3 |
| Molar Mass | 374.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xu H, et al. Dynamic observation of the radiosensitive effect of irisquinone on rabbit VX2 lung transplant tumors by using fluorine-18-deoxyglucose positron emission tomography/computed tomography. Nucl Med Commun. 2013 Mar;34(3):220-8. [2]. Wang H, et al. Radiosensitizing effect of irisquinone on glioma through the downregulation of HIF-1α evaluated by 18F-FDG and 18F-FMISO PET/CT. Nucl Med Commun. 2016 Jul;37(7):705-14. [3]. Liang, l., et al. The effect of Irisquinone on the glutathione system and MRP expression of cisplatin-resistant human lung adenocarcinoma cell line (A DDP549). Chin J Cancer Res 13, 171–175 (2001). |