| Bioactivity | Ir-UA is an usnic acid-derived iridium(III) complex that enhances PD-L1 expression and converts "cold tumors" into "hot tumors." Ir-UA stimulates PD-L1 expression by explicitly regulating the PD-L1 transcription factor[1]. |
| CAS | 3033235-42-3 |
| Formula | C52H43F6IrN5O6P2+ |
| Molar Mass | 1171.11 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Deng D, et al. Iridium(III)-Based PD-L1 Agonist Regulates p62 and ATF3 for Enhanced Cancer Immunotherapy. J Med Chem. 2024 Apr 25;67(8):6810-6821. |
Ir-UA
CAS: 3033235-42-3 F: C52H43F6IrN5O6P2+ W: 1171.11
Ir-UA is an usnic acid-derived iridium(III) complex that enhances PD-L1 expression and converts "cold tumors" into "hot
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