| Bioactivity | Ir-CA is an antitumor agent. Ir-CA can accumulate in mitochondria and induces mitochondria dysfunction. Ir-CA induces apoptosis and autophagy. Ir-CA initiates mitophagy and cell cycle arrest to kill Cisplatin (HY-17394)-resistant A549R cells. Ir-CA can effectively inhibit metastasis by inhibiting MMP-2/MMP-9[1]. |
| Invitro | Ir-CA 对 A549、A549R、HLF、BEAS-2B、MCF-7、4T1 细胞具有细胞毒性，IC50s 分别为 4.4、4.5、6.6、2.3、2.6、5.7 μM [1]。Ir-CA 很快被 A549R 细胞吸收 (孵育 1 小时后出现红色荧光)[1]。Ir-CA (10 μM，2 小时) 可在 A549 和 A549R 活细胞的线粒体中积聚 (Ir-CA 与 Mito-Tracker 的共染色实验)[1]。Ir-CA (10 μM，24 小时) 会损害 A549R 细胞的线粒体形态和线粒体功能，并诱导 ROS 产生[1]。Ir-CA (10 μM，24 小时) 通过非凋亡/坏死途径诱导 A549R 细胞凋亡，并且还增加从 LC3-I 到 LC3-II 的转化，表明存在自噬[1]。 Ir-CA (2.5 μM，24 小时) 使 A549R 细胞对顺铂 (HY-17394) 重新敏感[1]。Ir-CA (5 μM，24 h) 通过下调 MMP 抑制 A549R 细胞的转移[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Ir-CA 相关抗体: |
| In Vivo | Ir-CA (5 mg/kg，腹腔注射，每隔一天一次，持续 8 d) 抑制转移小鼠模型 (通过尾静脉注射 A549 细胞) 中 A549 细胞的肺转移[1]。Ir-CA (5 mg/kg，腹腔注射，每隔一天一次，持续 14 天) 抑制 A549 荷瘤 Balb/c 裸鼠的肿瘤生长[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 2870682-93-0 |
| Formula | C43H35F6IrN5OP |
| Molar Mass | 974.95 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yang J, et al. Consolidating Organometallic Complex Ir-CA Empowers Mitochondria-Directed Chemotherapy against Resistant Cancer via Stemness and Metastasis Inhibition. Inorg Chem. 2024 Mar 7. |
Ir-CA
CAS: 2870682-93-0 F: C43H35F6IrN5OP W: 974.95
Ir-CA is an antitumor agent. Ir-CA can accumulate in mitochondria and induces mitochondria dysfunction. Ir-CA induces ap
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.