| Bioactivity | lota-conotoxin RXIA is an agonist of voltage-gatedsodium channels (Nav1.2, 1.6, 1.7). Iota-conotoxin RXIAcan induce repetitive action potential and seizure in motor axons of frogsafter intracranial injection in mice [1]. |
| Name | Iota-conotoxin RXIA |
| CAS | 1042682-52-9 |
| Sequence | Gly-{Hyp}-Ser-Phe-Cys-Lys-Ala-Asp-Glu-Lys-{Hyp}-Cys-Glu-Tyr-His-Ala-Asp-Cys-Cys-Asn-Cys-Cys-Leu-Ser-Gly-Ile-Cys-Ala-{Hyp}-Ser-Thr-Asn-Trp-Ile-Leu-Pro-Gly-Cys-Ser-Thr-Ser-Ser-Phe-{d-Phe}-Lys-Ile (Disulfide bridge:Cys5-Cys19;Cys12-Cys22;Cys18-Cys27;Cys21-Cys38) |
| Shortening | G-{Hyp}-SFCKADEK-{Hyp}-CEYHADCCNCCLSGICA-{Hyp}-STNWILPGCSTSSF-{d-Phe}-KI (Disulfide bridge:Cys5-Cys19;Cys12-Cys22;Cys18-Cys27;Cys21-Cys38) |
| Formula | C212H310N54O69S8 |
| Molar Mass | 4975.57 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Fiedler B, et al. Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels Na(V)1.2, 1.6 and 1.7. Biochem Pharmacol. 2008 Jun 15;75(12):2334-44. |
Iota-conotoxin RXIA
CAS: 1042682-52-9 F: C212H310N54O69S8 W: 4975.57
lota-conotoxin RXIA is an agonist of voltage-gatedsodium channels (Nav1.2, 1.6, 1.7). Iota-conotoxin RXIAcan induce repe
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