Inuviscolide_product_DataBase

Bioactivity	Inuviscolide is an apoptosis inducer. Inuviscolide can induce of G2/M arrest in human melanoma cell lines. Inuviscolide exhibits antineoplastic and anti-inflammatory activities[1][2][3].
Invitro	Inuviscolide (9-72 μM; 24 h) 抑制 SK-28，624 和 1363 黑色素瘤细胞的增殖，IC50 值分别为 37，41.1 和 39 μM[2]。Inuviscolide (36-54 μM; 4-24 h) 导致 SK-28 细胞在 G2/M 期发生剂量依赖性积累[2]。Inuviscolide (72 μM; 48 h) 导致约 70% 的 SK-28 细胞表现出早期凋亡标志物[2]。Inuviscolide 在 100 μM 时抑制人白细胞弹性蛋白酶的释放 51%[1]。Inuviscolide 抑制蜂毒分泌的 PLA2 (sPLA2)，IC50 值为 80.5 μM[1]。Inuviscolide 在 50 μM 时抑制 COX-1 (40%)，而它对诱导型 COX-2 没有活性[1]。 Cell Proliferation Assay[2] Cell Line:
Name	Inuviscolide
CAS	63109-30-8
Formula	C15H20O3
Molar Mass	248.32
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

PeptideDB