| Bioactivity | Intralipid is a safe fat emulsion that can be used as a nutritional supplement. Intralipid effectively inhibits the opening of the mitochondrial permeability transition pore, effectively protecting the heart from ischaemia-reperfusion injury and has some potential to modulate the innate immune response[1][2]. | ||||||||||||
| Invitro | Intralipid (0-0.2 mg/mL)可以特异性保护免疫细胞免受紫杉醇的侵害，但对肿瘤细胞无影响[1]。 Intralipid (0-0.2 mg/mL, 3 days) 可以促进M0、M1 和 M2 巨噬细胞极化为 M1 样表型[1]。 | ||||||||||||
| In Vivo | Intralipid (2 g/kg) 在 Balb/c 小鼠乳腺癌肿瘤切片中观察到其不影响吞噬作用，并可能促进巨噬细胞极化为 M1 表型[1]。 Intralipid 预处理可以促进紫杉醇在肿瘤组织中的积累并诱导更高水平的肿瘤细胞凋亡。增加紫杉醇在小鼠 RES 器官中的分布， 以及增强其对肿瘤生长的抑制作用[1]。 Intralipid (5 mL/kg)在 SD 大鼠中比环孢菌素-A 可以更有效地保护心脏免受 I/R 损伤，可使心肌梗塞面积缩小约 40%[2]。 | ||||||||||||
| Name | Intralipid | ||||||||||||
| CAS | 68890-65-3 | ||||||||||||
| Appearance | Solid-liquid mixture | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Yen-Ju Chen, et al. Impacts of Intralipid on Nanodrug Abraxane Therapy and on the Innate Immune System. Sci Rep. 2020 Feb 18;10(1):2838. [2]. Jingyuan Li, et al. Intralipid, a clinically safe compound, protects the heart against ischemia-reperfusion injury more efficiently than cyclosporine-A. Anesthesiology. 2012 Oct;117(4):836-46. |