| Bioactivity | Influenza virus-IN-3 (compound 9) is a potent and selective influenza virus inhibitor with IC50s of 0.88, 0.10, 5.5, 0.51 µM for H5N1, H5N2, H5N6, H5N8, respectively. Influenza virus-IN-3 shows antiviral and NA (neuraminidase enzyme)-inhibitory activity. Influenza virus-IN-3 shows low cytotoxicity with an CC50 of >200 µM[1]. |
| Target | IC50: 0.88 µM (H5N1); 0.10 µM (H5N2); 5.5 µM (H5N6); 0.51 µM (H5N8) |
| Invitro | Influenza virus-IN-3 (compound 9a) shows NA (neuraminidase enzyme)-inhibitory activity with IC50s of 118.17, 1442.6, 34543.33, 78.06, 10206, 0.00048, 0.01222 nM for H5N1, H5N2, H5N6, H5N8, H5N1eH274Y, N1 (H1N1pdm09) and N2 (H3N2), respectively[1]. |
| Name | Influenza virus-IN-3 |
| CAS | 2412451-16-0 |
| Formula | C25H32N2O4S |
| Molar Mass | 456.60 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ai W, et al. Discovery of novel "Dual-site" binding oseltamivir derivatives as potent influenza virus neuraminidase inhibitors. Eur J Med Chem. 2020 Apr 1;191:112147. |
Influenza virus-IN-3
CAS: 2412451-16-0 F: C25H32N2O4S W: 456.60
Influenza virus-IN-3 (compound 9) is a potent and selective influenza virus inhibitor with IC50s of 0.88, 0.10, 5.5, 0.5
Data collection：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.