Influenza A virus-IN-8_product_DataBase

Bioactivity	Influenza A virus-IN-8 (S5) is a macrocyclic peptide with no cytotoxic. Influenza A virus-IN-8 is also a potent Influenza A Virus (IAV) inhibitor (with sufficient protease stability) with IC50s of 6.7 and 6.6 nM for H1 and H5 variants, respectively. Influenza A virus-IN-8 shows good affinitiescan to H1 variants, binds to a conserved region in the HA stem with a Kd of 1.0 nM[1].
Invitro	Influenza A virus-IN-8 (5 μM; 72 h) does not affect viability of HeLa and MDCKI cells[1].Influenza A virus-IN-8 (5 μM; 24 h) shows neutralizing effect on H1N1pdm09 and H5N1 in a dose-dependent manner[1].Influenza A virus-IN-8 (5 nM; 2 h) binds to a conserved region in the HA stem with Kd of 1.0 nM for H1 variants[1].Influenza A virus-IN-8 (5 μM; 1 h) inhibits HA fusion activity during entry by stabilizing the prefusion conformation[1]. Cell Viability Assay[1] Cell Line:
Name	Influenza A virus-IN-8
Formula	C104H142N28O24S
Molar Mass	2200.48
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

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