Influenza A virus-IN-7_product_DataBase

Bioactivity	Influenza A virus-IN-7 (compound 16r) is a potent and orally active influenza A virus inhibitor with an IC50 of 3.43 µM and CC50 of >100 µM. Influenza A virus-IN-7 shows anti-IAV activity with low cytotoxicity. Influenza A virus-IN-7 inhibits the transcription and replication of viral RNA[1].
Target	IC50: 3.43 µM (influenza virus); CC50: >100 µM (influenza virus)
In Vivo	Influenza A virus-IN-7 (compound 16r) (1.25 mg/kg for i.v.; 25 mg/kg for p.o.) shows good PK profiles with oral bioavailability of 22.5%[1]. Animal Model:
Name	Influenza A virus-IN-7
CAS	2464415-40-3
Formula	C29H25N5O
Molar Mass	459.54
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Zhang G, et al. Design, synthesis and in vitro anti-influenza A virus evaluation of novel quinazoline derivatives containing S-acetamide and NH-acetamide moieties at C-4. Eur J Med Chem. 2020 Nov 15;206:112706.

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